Synthesis and Investigation of Anti-Bacterial Activity of N-(3-aminophenyl)-N'-(prop-2-en-1-yl) Thiourea Compound

Abstract

N-(3-aminophenyl)-N'-(prop-2-en-1-yl) thioureas was synthesized from halogenated aromatic amines reflux with N-prop-2en-1-yl thioureas in isopropanol. Synthesized compound was characterized using FT-IR, NMR, Mass spectra and CHNS-elemental and Chemical analysis. Further, antibacterial activity of compound was examined against gram-positive and gram-negative bacteria strains such as Escherichia Coil, Pseudomonas Aeruginosa, Mycobacterium Tuberculosis, Enterococcus Faecalis, and Staphylococcus Aureusin by using disk diffusion method. Susceptibility of bacterial strains against compound was tested with standard antibiotic ciprofloxacin. Outcome of test displayed good antibacterial activity against Pseudomonas Aeruginosa, Mycobacterium Tuberculosis, Staphylococcus Aureusin than Escherichia Coil and Enterococcus Faecalis bacterial strain.