Antifungal Activity of Aniline-Enfolded Substituted Thiourea Derivatives

Abstract

Antifungal fugal activity of substituted thiourea derivatives enfolded with aniline tested against fungal strain Aspergillus Niger and Candida albicans. New series of thiourea derivatives were synthesized from aniline reflux with substituted thiourea. The antifungal activity of compounds was confirmed by Zone Inhibition Method in concentration of 50–1000 μg/mL. Substituted thiourea derivatives enfolded with aniline exhibited the most potent antifungal activity against fungal strain Aspergillus Niger, Candida albicans. These alkyl and acyl thioureas derivatives had significant inhibitory effect on the fungal strain. Minimum inhibition concentration (MIC) values in mm of antifungal thioureas derivative at max. Conc. 1000 μg/mL against Aspergillus niger strain were 13.67, 15, 12 while against Candida albicans strain were 7.33, 11 and 13.7 respectively. The initial structure-function link suggests that allyl and aromatic groups enhanced antifungal activities.