Synthesis of Unusual Amino Acids

Abstract

Unusual amino acids, particularly β-, γ-, and other non-α variants, have attracted considerable attention in recent years due to
their applications in drug discovery, peptide-based therapeutics, and materials science. These modified amino acids exhibit unique
conformational flexibility, enhanced stability against enzymatic degradation, and the ability to mimic protein secondary structures. This
paper discusses the synthetic strategies employed for generating such amino acids, including asymmetric synthesis, multicomponent
reactions, and chemoenzymatic methods. Special focus is given to the synthesis of β-amino acids, their stereochemical challenges, and
their integration into bioactive compounds.