FLOATING TABLET OF SALBUTAMOL SULPHATE AND THEOPHYLLINE: DEVELOPMENT AND EVALUATION

Abstract

The aim of present research is to formulate and evaluate gastro retentive effervescent floating matrix
tablet of two anti-asthmatic drugs, Salbutamol sulphate and Theophylline which are often indicated for the management
of asthma, their frequent dosing may reduce compliance, thus making a prolonged release formulation necessary. Tablets
were prepared by wet granulation method using Hydroxy propyl methylcellulose (HPMC) as a release retardant agent
and sodium bicarbonate and Citric acid as a gas-generating agents. The prepared granules showed satisfactory flow
properties and compressibility. Formulations were evaluated for in vitro drug release profile and swelling characteristics.
The similarity factor and dissolution kinetics were used as parameters for selection of the best batch. The result of
formulation C7 batch showed the best result and was found to extend the release of Salbutamol Sulphate and
Theophylline upto 12 hr. and was found to be comparable with marketed sustained released tablet Theoasthalin SR
(Cipla). The in- vitro drug release followed Korsemeyer-Peppas kinetics and the drug release mechanism was found to be
of anomalous type i.e, swelling and diffusion.