IN-VITRO EVALUATION OF ANTIOXIDANT ACTIVITY OF 2’- HYDROXY CHALCONE

Abstract

Chalcone are important class of natural product, they are found to be much in use for their therapeutic
properties. They are also used as precursors for the synthesis of different heterocyclic derivatives. In the present work 2’-
hydroxy chalcone are synthesized by halogen substituted 2’-hydroxy acetophenone and orthofluorobenzaldehydes.
Chalcone are synthesized by Claisen-Schmidt condensation in the presence of aqueous 50% sodium hydroxide at room
temperature and assessed for their antioxidant activity. The structure of these chalcone have been determined by
physical and spectral method such as melting point, IR, MASS ,1 H-NMR spectroscopy.