EXTRACTION AND PARTIAL PURIFICATION OF BETA-AMYRIN FROM CRUDE METHANOLIC LEAF EXTRACTS OF ALOE VERA L. FOR ITS TOPICAL ANTI-INFLAMMATORY ACTIVITY ON ALBINO MICE

Abstract

The present research work was undertaken to extract and isolate beta amyrin from Aloe vera L. which is one of
the well-known medicinal plants in Ayurveda. The latex of this plant is commonly termed as Aloe, which shows prominent
active ingredients in it. The topical application of aloe is well practised traditionally. The most important constituents of aloes
are the two aloins, namely barbaloin and isobarbaloin with small portion of beta-amyrin (Oleanane skeleton). The main
course and basic treatment line for inflammatory diseases remain one of the major health problems. Hence in present work
isolated and partially purified beta amyrin gel was formulated and was employed to reduce induced inflammation topically in
1-4 hour time period. Spectral studies confirmed the presence of beta amyrin. Topical anti-inflammatory activity using mice
paw confirms 54.59% activity with 2 mg/kg concentration