Aspartic Acid (Amino Acid)-Cu(II) Complex Via Potentiometric Method And Study Of Its Stability Constant, Thermodynamic Parameters And Antimicrobial Effect

Abstract

The Aspartic acid-Cu(II) complex is a coordination compound formed by the binding of copper(II) ions with aspartic acid, an essential amino acid, exhibiting potential biological and pharmacological applications. This study investigates the complexation behavior between aspartic acid and Cu(II) ions using potentiometric titration methods at varying temperatures (303K, 308K, and 313K) under controlled ionic strength conditions. The stability constants of the Cu(II)-aspartic acid complex were determined using the modified Irving-Rossotti technique. Thermodynamic parameters including Gibbs free energy (ΔG), enthalpy change (ΔH), and entropy change (ΔS) were calculated to understand the spontaneity and nature of the complexation process. The proton-ligand stability constants (pKa) and metal-ligand stability constants (log K) were evaluated at different temperatures. Additionally, the antimicrobial activity of the synthesized complex was assessed against selected bacterial strains using standard protocols to explore its potential therapeutic applications. The complex formation was confirmed through various physicochemical techniques, and the results indicate the formation of stable coordination compounds under the experimental conditions.