Lower Urinary Tract Symptoms Diagnosis by Uropine: A MEMS based economic urodynamic system

Abstract

Lower urinary tract symptoms, or LUTS, are a major and common urological burden that impacts a wide range of people of all ages and genders. Two potential causes of LUTS are neurogenic bladder dysfunction and benign prostatic hyperplasia (BPH) [1].  Urodynamic study (UDS), a functional evaluation of bladder and urethra, is a standard diagnostic procedure for these conditions[2]. However, high cost, lack of portability, and operational complexity of multi-lumen catheterization and laborious fluid-filled pressure transmission lines are characteristics of conventional urodynamic instrumentation[2][3]. These restrictions significantly limit urological care accessibility, especially in rural and resource-constrained settings. Thorough hardware design, engineering process, and clinical validation of "Uropine," a novel, inexpensive, AI-powered portable biomedical device intended to upend a established paradigm of LUTS diagnosis, are described in this research paper.

Uropine system provides real-time, high-fidelity monitoring of intra-vesical pressure (IBP) and intra-abdominal pressure (IAP) by combining sophisticated Micro-Electro-Mechanical Systems (MEMS) pressure transduction technology with an easy-to-use single-catheter interface. This report provides a thorough technical analysis of hardware subsystems of a device, covering topics such as implementation of embedded microcontroller-based data acquisition, design of high-precision analog signal conditioning circuits using instrumentation amplifiers, and physics of piezoresistive sensing elements. This study establishes Uropine as a feasible, scalable hardware platform that can provide tertiary-grade diagnostic precision in a portable form factor by combining theoretical biomedical engineering principles with empirical clinical data.