FORMULATION AND EVALUATION OF MOUTH DISSOLVING DRUG DELIVERY SYSTEM OF PANTOPRAZOLE SODIUM

Abstract

Oral routes of drug administration have wide acceptance up to 50-60% of total dosage forms. Solid dosage forms
are popular because of ease of administration, accurate dosage, selfmedication, pain avoidance and most importantly the patient
compliance. Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablet. In the
present study, an attempt has been made to formulate fast dissolving tablets of Pantoprazole Sodium Sesquihydrate using
superdisintegrants such as Croscarmellose sodium (Ac‐Di‐Sol), Sodium starch glycolate (Explotab) and Crosspovidone by direct
compression technique. The prepared tablets were evaluated for hardness, friability, wetting time, weight variation, in vitro
disintegration time and in vitro dissolution study. The hardness of the tablets was in the range of 3.0 ‐ 4.0 Kg/cm². The percentage
friability of the tablets was less than one. Weight variation test results showed that the tablets were deviating from the average
weight within the permissible limits of ±7.5 %. Drug content uniformity study results showed the uniform dispersion of the drug
throughout the formulation i.e. 98.54% to 101.23%. Tablets containing Crosspovidone (F9) showed better disintegrating
character along with the rapid release (99.83% drug within 4 minutes). No appreciable difference was found between the
formulations containing other two superdisintegrants. Crosspovidone was found to be better suited for the formulation of mouth
dissolving tablet of Pantoprazole Sodium Sesquihydrate compared to other superdisintegrarnts used in thestudy